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Article

Comprehensive summary: the role of PBX1 in development and cancers

26 Jul 2024

Abstract excerpt

PBX1 is a transcription factor that can promote the occurrence of various tumors and play a reg-ulatory role in tumor growth, metastasis, invasion, and drug resistance. Furthermore, a variant generated by fusion of E2A and PBX1, E2A-PBX1, has been found in 25% of patients with childhood acute lymphoblastic leukemia. Thus, PBX1 is a potential therapeutic target for many cancers. Here, we describe the structure of...

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Identifiers

PMID: 39129784
DOI: 10.3389/fcell.2024.1442052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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