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PBX1: a TALE of two seasons—key roles during development and in cancer

9 Feb 2024

Abstract excerpt

Pre-B cell leukemia factor 1 (PBX1) is a Three Aminoacid Loop Extension (TALE) homeodomain-containing transcription factor playing crucial roles in organ pattering during embryogenesis, through the formation of nuclear complexes with other TALE class and/or homeobox proteins to regulate target genes. Its contribution to the development of several organs has been elucidated mainly through the study of murine...

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PMID: 38404687
DOI: 10.3389/fcell.2024.1372873

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