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Prevalence of molecular markers of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum isolates from West Africa during 2012-2022.

Scientific reports - 4 Nov 2024

Zhou Ruimin, Li Suhua, Ji Penghui, Ruan Shucheng, Liu Ying, Yang Chengyun, Qian Dan, He Zhiquan, Wang Dan, Lu Deling, Zhang Hongwei, Deng Yan

Abstract excerpt

Sulfadoxine-pyrimethamine (SP) is a key drug recommended by the World Health Organization for the chemoprevention of malaria. However, the strategy is affected by the parasite resistance to SP. This study evaluated Plasmodium falciparum dihydrofolate reductase (Pfdhfr) and dihydropteroate synthase (Pfdhps) genes, associated with SP resistance, from 508 P. falciparum isolates imported from West African countries...

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Africa, Western
Antimalarials
Dihydropteroate Synthase
Drug Combinations
Malaria, Falciparum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tetrahydrofolate Dehydrogenase

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Identifiers

PMID: 39496624
DOI: 10.1038/s41598-024-75828-w
PMCID: PMC11535326

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