Article
Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next?
Trends in parasitology - 1 Dec 2001
Sibley C H, Hyde J E, Sims P F, Plowe C V, Kublin J G, Mberu E K, Cowman A F, Winstanley P A, Watkins W M, Nzila A M
Abstract excerpt
Chemotherapy remains the only practicable tool to control falciparum malaria in sub-Saharan Africa, where >90% of the world's burden of malaria mortality and morbidity occurs. Resistance is rapidly eroding the efficacy of chloroquine, and the combination pyrimethamine-sulfadoxine is the most commonly chosen alternative. Resistant populations of Plasmodium falciparum were selected extremely rapidly in Southeast...
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