Article
Pyrimethamine/sulfadoxine combination in the treatment of uncomplicated falciparum malaria: relation between dihydropteroate synthase/dihydrofolate reductase genotypes, sulfadoxine plasma levels, and treatment outcome.
The American journal of tropical medicine and hygiene - 1 Sept 2002
Khalil Insaf, Alifrangis Michael, Rønn Anita M, Gabar Haythem A, Jelinek Tomas, Satti Gwiria M H, Bygbjerg Ib C
Abstract excerpt
Several in vitro studies have shown the correlation between mutations in dhfr and dhps genes and resistance to pyrimethamine/sulfadoxine (PYR/SDX) combination, but the in vivo correlates of these mutations with PYR/ SDX efficacy have not been investigated fully. We assessed PYR/SDX efficacy in relation to the frequency of dhfr and dhps mutations in 37 Plasmodium falciparum isolates sampled before treatment....
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