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Article

Antifolates can have a role in the treatment of Plasmodium vivax.

Trends in parasitology - 1 May 2007

Hawkins Vivian N, Joshi Hema, Rungsihirunrat Kanchana, Na-Bangchang Kesara, Sibley Carol Hopkins

Abstract excerpt

Plasmodium vivax is a serious health concern in many regions and is sometimes inadvertently treated with sulfadoxine-pyrimethamine (SP). Mutations in the genes that encode dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) confer resistance to pyrimethamine and sulfadoxine, respectively. Numerous studies have examined the prevalence and diversity of mutations in P. vivax dhfr and some have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17368986
DOI: 10.1016/j.pt.2007.03.002

Genes

DHFR
DHPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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