Article
RETROSPECTIVE INVESTIGATION OF PYRIMETHAMINE-SULFADOXINE RESISTANCE INDICATORS IN FALCIPARUM-MALARIA POSITIVE BLOOD SAMPLES FROM SOUTH-WESTERN SAUDI ARABIA.
Journal of the Egyptian Society of Parasitology - 1 Aug 2016
Al-Harthi Saeed A
Abstract excerpt
The efficacy of Sulphadoxine/Pyrimethamine (SP) in Plasmodium falciparum malaria treatment was increasingly compromised by development of parasites' resistance. Saudi Arabia shifted to new combinations including Artesunat compound during the last decade. We investigated the occurrence of mutations in P. falciparum dihydrofolate reductase (Pfdhfr) N51I, C59R and S108N and P. falciparum dihyropteroate synthetase...
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