Article
Low frequency of CYP2A6 gene polymorphism as revealed by a one-step polymerase chain reaction method.
Pharmacogenetics - 1 Jun 1999
Chen G F, Tang Y M, Green B, Lin D X, Guengerich F P, Daly A K, Caporaso N E, Kadlubar F F
Abstract excerpt
Human cytochrome P450 2A6 (CYP2A6) has been shown to metabolically activate carcinogens and mutagens. Genetic polymorphisms for CYP2A6 have been reported previously in different ethnic groups using a two-step polymerase chain reaction (PCR) method to identify CYP2A6*1, CYP2A6*2 and CYP2A6*3. Moreover, a new truncated allele has been recently identified in a Japanese population. We report here a one-step PCR...
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