Article
Detection of CYP2D6*3 and 2D6*4 allelic variants by PCR-restriction fragment length polymorphism.
Clinical chemistry and laboratory medicine - 1 Aug 1998
Topić E, Stefanović M, Nikolić V, Zoricić I, Ivanisević A M, Zuntar I
Abstract excerpt
The mutant of CYP2D6*3 allele with A2637 deletion in exon 5 and the mutant of CYP2D6*4 allele G1934-->A, splice site defect are among the most common polymorphic alleles of CYP2D6 gene, resulting in a decreased or no activity of CYP isoenzyme. In this study, a reliable polymerase chain reaction-r...
Topics
- Alleles
- Base Sequence
- Breast Neoplasms
- Carcinoma, Squamous Cell
- Cytochrome P-450 CYP2D6
- DNA Primers
- Head and Neck Neoplasms
- Humans
- Isoenzymes
- Liver Cirrhosis
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length