Article
Multidrug resistance phenotype in the RMS-GR human rhabdomyosarcoma cell line obtained after polychemotherapy.
Japanese journal of cancer research : Gann - 1 Jul 1999
Prados J, Melguizo C, Marchal J A, Vélez C, Alvarez L, Aránega A
Abstract excerpt
Classical cytotoxic treatment of rhabdomyosarcoma (RMS), the most common soft tissue malignacy in children, is often accompanied by significant morbidity and poor response. Chemotherapy may induce multidrug resistance (MDR) associated with the expression of P-glycoprotein, a drug efflux pump which modifies the sensitivity of tumoral cells to drugs. To analyze MDR in RMS we used the RMS-GR cell line, obtained from...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Blotting, Southern
- Child, Preschool
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Flow Cytometry
- Gene Expression
- Humans
- Infant
- Phenotype
- Polymerase Chain Reaction
- Rhabdomyosarcoma
- Soft Tissue Neoplasms