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Article

Up-regulation of GLI1 in vincristine-resistant rhabdomyosarcoma and Ewing sarcoma

3 Jun 2020

Abstract excerpt

BACKGROUND: The clinical significance of GLI1 expression either through canonical Hedgehog signal transduction or through non-canonical mechanisms in rhabdomyosarcoma (RMS) or Ewing sarcoma (EWS) is incompletely understood. We tested a role for Hedgehog (HH) signal transduction and GL11 expression in development of vincristine (VCR) resistance in RMS and EWS. METHODS: compared with parental cells. We determined...

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PMID: 32493277
DOI: 10.1186/s12885-020-06985-0

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