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Article

Establishment of cisplatin-resistant variants of human neuroblastoma cell lines, TGW and GOTO, and their drug cross-resistance profiles.

Cancer chemotherapy and pharmacology - 1 Jun 2002

Iwasaki Iwao, Sugiyama Hisahiko, Kanazawa Shinsaku, Hemmi Hiromichi

Abstract excerpt

PURPOSE: The emergence of multidrug resistance (MDR) in neuroblastoma is a critical issue for chemotherapy. In order to study low-level MDR, we developed variants derived from two neuroblastoma cell lines, TGW and GOTO, by exposure to low doses of cisplatin (CDDP). The cross-resistance to other cytotoxic agents and expression of MDR-related proteins in the variants and their clones were examined. MATERIALS AND...

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Identifiers

PMID: 12107547
DOI: 10.1007/s00280-002-0452-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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