Sequential emergence ofMRP- andMDR1-gene over-expression as well asMDR1-gene translocation in homoharringtonine-selected K562 human leukemia cell lines

Abstract excerpt

To investigate the mechanism of resistance to an antineoplastic natural product homoharringtonine (HHT) in leukemic cells, we have established 5 sub-lines of human myeloid leukemia K562 cells, designated as K-H30, K-H100, K-H200, K-H300 and K-H400, which showed progressive resistance to different concentrations of HHT. These sub-lines were cross-resistant to daunorubicin, vincristine, etoposide and mitoxantrone,...

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