Multiple drug-resistance in variant of a human non-small cell lung carcinoma cell line, DLKP-A.

doi:10.1007/BF00376102

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Article

Multiple drug-resistance in variant of a human non-small cell lung carcinoma cell line, DLKP-A.

Cytotechnology - 1 Jan 1992

Clynes M, Redmond A, Moran E, Gilvarry U

Abstract excerpt

A 300-fold adriamycin resistant variant (DLKP-A) of the human lung squamous cell carcinoma line DLKP was established by stepwise selection in increasing concentrations of adriamycin. Different levels of cross-resistance were observed towards VP-16, VM-26, colchicine, vincristine and, somewhat unexpectedly, cis-platin. Resistance was stable for at least 3 months in culture in the absence of drug. P-glycoprotein...

Topics

Antineoplastic Agents
Base Sequence
Blotting, Western
Carcinoma, Non-Small-Cell Lung
Chromosome Banding
Culture Techniques
Doxorubicin
Drug Resistance
Fluorescent Antibody Technique
Genetic Variation
Glycoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Lung Neoplasms

Male

Metaphase

Middle Aged

Molecular Sequence Data

Oligonucleotides, Antisense

Source

Open in PubMed

Identifiers

PMID: 1369413
DOI: 10.1007/BF00376102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1369413-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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