Article

Human fibrosarcoma cells selected for very-high doxorubicin resistance, acquire trabectedin and eribulin cross-resistance, remain sensitive to recombinant methioninase, and have increased c-MYC expression

2025-06-11

Abstract excerpt

Doxorubicin is first-line chemotherapy for soft tissue sarcoma; however, the development of drug resistance limits its efficacy. The purpose of the present study was to select very-high doxorubicin-resistant (VHDR) HT1080 fibrosarcoma cells, determine cross-resistance to second-line chemotherapy drugs, determine maintenance of sensitivity to recombinant methioninase (r-METase) alone and in combination with doxorub...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f1a31d93-2d54-555b-a806-7344ce0c0fe2
DOI: 10.1101/2025.06.07.658455

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human fibrosarcoma cells selected for very-high doxorubicin resistance, acquire trabectedin and eribulin cross-resistance, remain sensitive to recombinant methioninase, and have increased c-MYC expressionDOI 10.1101/2025.06.07.658455Read

Perspectives of Cell Sensitivity/Resistance Assay in Soft Tissue Sarcomas ChemotherapySemantic proximity Read

Addressing Doxorubicin Resistance in Bone Sarcomas Using Novel Drug-Resistant ModelsSemantic proximity Read

Overcome Resistance in Doxorubicin-Adapted Hodgkin Lymphoma Cells With Acquired Multidrug Resistance and Improved Immunosuppressive AbilitiesSemantic proximity Read

CG5/Dx human breast cancer cell line: characterization of a new doxorubicin-resistant variant.Semantic proximity Read

miR-197-5p increases Doxorubicin-mediated anticancer cytotoxicity of HT1080 fibrosarcoma cells by decreasing drug effluxSemantic proximity Read

Effect of Transient Hypoxia on Sensitivity to Doxorubicin in Human and Murine Cell LinesSemantic proximity Read

Different Doxorubicin Sensitivity Across Various Human Cancer Cell LinesSemantic proximity Read

Drug resistance patterns of human neuroblastoma cell lines derived from patients at different phases of therapy.Semantic proximity Read

Extreme sensitivity to Yondelis (Trabectedin, ET-743) in low passaged sarcoma cell lines correlates with mutated p53.Semantic proximity Read

Multidrug resistance phenotype in the RMS-GR human rhabdomyosarcoma cell line obtained after polychemotherapy.Semantic proximity Read

Carboxymethylcellulose-based and docetaxel-loaded nanoparticles circumvent P-glycoprotein-mediated multidrug resistance.Semantic proximity Read

Enhancement of the loss of multiple drug resistance by hydroxyurea.Semantic proximity Read