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Article

CHK1 frameshift mutations in genetically unstable colorectal and endometrial cancers

1 Oct 1999

Abstract excerpt

The protein encoded by the CHK1 gene plays an important role in the G2 checkpoint in mammalian cells. In its coding region it presents a sequence of nine consecutive adenines that are a potential site of mutations in tumors with microsatellite instability (MSI). We analyzed the presence of frameshift mutations in the CHK1 gene in human colon and endometrial cancer samples. In the same cancer samples genes known...

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PMID: 10469457
DOI: 10.1002/(sici)1098-2264(199910)26:2<176::aid-gcc11>3.0.co;2-3

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