Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic frameshift mutations in the Bloom syndrome BLM gene are frequent in sporadic gastric carcinomas with microsatellite mutator phenotype.

BMC genetics - 1 Jan 2001

Calin G, Ranzani G N, Amadori D, Herlea V, Matei I, Barbanti-Brodano G, Negrini M

Abstract excerpt

BACKGROUND: Genomic instability has been reported at microsatellite tracts in few coding sequences. We have shown that the Bloom syndrome BLM gene may be a target of microsatelliteinstability (MSI) in a short poly-adenine repeat located in its coding region. To further characterize the involvement of BLM in tumorigenesis, we have investigated mutations in nine genes containing coding microsatellites in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Carcinoma

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Helicases

Share to Frameshift Mutation

Share to Microsatellite Repeats

Share to Poly A

Share to RecQ Helicases

Share to Stomach Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 11532193
DOI: 10.1186/1471-2156-2-14
PMCID: PMC48142

Genes

BLM
BAX
CBL
RECQL
WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic frameshift mutations in the Bloom syndrome BLM gene are frequent in sporadic gastric carcinomas with microsatellite mutator phenotype.PMID 11532193Read ↗

The coding region of the Bloom syndrome BLM gene and of the CBL proto-oncogene is mutated in genetically unstable sporadic gastrointestinal tumors.Semantic proximity Read ↗

Frameshift somatic mutations in gastrointestinal cancer of the microsatellite mutator phenotype.Semantic proximity Read ↗

Mutations in TGFbeta-RII and BAXmediate tumor progression in the later stages of colorectal cancer with microsatellite instabilitySemantic proximity Read ↗

Frameshift mutations at mononucleotide repeats in caspase-5 and other target genes in endometrial and gastrointestinal cancer of the microsatellite mutator phenotype.Semantic proximity Read ↗

Gastric cancers of the microsatellite mutator phenotype display characteristic genetic and clinical features.Semantic proximity Read ↗

Mutations at coding mononucleotide repeats in gastric cancer with the microsatellite mutator phenotype.Semantic proximity Read ↗

Significance of mutations in TGFBR2 and BAX in neoplastic progression and patient outcome in sporadic colorectal tumors with high-frequency microsatellite instability.Semantic proximity Read ↗

Germline and somatic mutations in hMSH6 and hMSH3 in gastrointestinal cancers of the microsatellite mutator phenotype.Semantic proximity Read ↗

Three new BLM gene mutations associated with Bloom syndrome.Semantic proximity Read ↗

Low mutation incidence in polymorphic noncoding short mononucleotide repeats in gastrointestinal cancer of the microsatellite mutator phenotype pathway.Semantic proximity Read ↗

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.Semantic proximity Read ↗

Somatic frameshift alterations in mononucleotide repeat-containing genes in different tumor types from an HNPCC family with germline MSH2 mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.