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Frameshift mutations at coding mononucleotide repeat microsatellites in endometrial carcinoma with microsatellite instability

15 May 2000

Abstract excerpt

BACKGROUND: Microsatellite instability (MI) is a frequent occurrence in endometrioid carcinoma of the endometrium (EC). Several genes known to contain mononucleotide short tracts in their coding sequences (TGF-beta RII, IGFIIR, BAX, hMSH6, and hMSH3) are likely targets for mutations in these tumors. METHODS: DNA from 24 patients with EC and MI was extracted from blood and from fresh-frozen and paraffin embedded...

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PMID: 10820351
DOI: 10.1002/(sici)1097-0142(20000515)88:10<2290::aid-cncr13>3.0.co;2-i

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