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Article

Origin and Evolution of the Human Bcl2-Associated Athanogene-1 (BAG-1).

International journal of molecular sciences - 18 Dec 2020

Nguyen Peter, Hess Kyle, Smulders Larissa, Le Dat, Briseno Carolina, Chavez Christina M, Nikolaidis Nikolas

Abstract excerpt

Molecular chaperones, particularly the 70-kDa heat shock proteins (Hsp70s), are key orchestrators of the cellular stress response. To perform their critical functions, Hsp70s require the presence of specific co-chaperones, which include nucleotide exchange factors containing the BCL2-associated athanogene (BAG) domain. BAG-1 is one of these proteins that function in a wide range of cellular processes, including...

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PMID: 33353252
DOI: 10.3390/ijms21249701
PMCID: PMC7766421

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