Article
The transcription factor GATA-1 is overexpressed in breast carcinomas and contributes to survivin upregulation via a promoter polymorphism.
Oncogene - 29 Apr 2010
Boidot R, Végran F, Jacob D, Chevrier S, Cadouot M, Feron O, Solary E, Lizard-Nacol S
Abstract excerpt
Expression of survivin, a member of the inhibitor of apoptosis protein family, is elevated in human cancers and considered as a new therapeutic target. Mechanism upregulating survivin expression in tumour cells is poorly understood. In this study, we show that breast cancer patients harbouring a polymorphism G235A in the survivin promoter present a higher level of survivin expression. This polymorphism creates a...
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