High Frequency of β-Catenin Mutations in Mouse Hepatocellular Carcinomas Induced by a Nongenotoxic Constitutive Androstane Receptor Agonist.

doi:10.1016/j.ajpath.2018.07.022

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Article

High Frequency of β-Catenin Mutations in Mouse Hepatocellular Carcinomas Induced by a Nongenotoxic Constitutive Androstane Receptor Agonist.

The American journal of pathology - 1 Nov 2018

Mattu Sandra, Saliba Christian, Sulas Pia, Zavattari Patrizia, Perra Andrea, Kowalik Marta A, Monga Satdarshan P, Columbano Amedeo

Abstract excerpt

Activation of Wnt/β-catenin signaling is frequent in human and rodent hepatocarcinogenesis. Although in mice the tumor-promoting activity of agonists of constitutive androstane receptor (CAR) occurs by selection of carcinogen-initiated cells harboring β-catenin mutations, the molecular alterations leading to hepatocellular carcinoma (HCC) development by the CAR agonist 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene...

Topics

Animals
Carcinoma, Hepatocellular
Constitutive Androstane Receptor
Female
Liver Neoplasms, Experimental
Mice
Mice, Inbred C3H
Mutation
Pyridines
Receptors, Cytoplasmic and Nuclear
beta Catenin

Source

Open in PubMed

Identifiers

PMID: 30201494
DOI: 10.1016/j.ajpath.2018.07.022

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