Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4.

doi:10.1126/science.272.5265.1170

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Article

Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4.

Science (New York, N.Y.) - 24 May 1996

Marengère L E, Waterhouse P, Duncan G S, Mittrücker H W, Feng G S, Mak T W

Abstract excerpt

The absence of CTLA-4 results in uncontrolled T cell proliferation. The T cell receptor-specific kinases FYN, LCK, and ZAP-70 as well as the RAS pathway were found to be activated in T cells of Ctla-4-/- mutant mice. In addition, CTLA-4 specifically associated with the tyrosine phosphatase SYP, a...

Topics

Abatacept
Adaptor Proteins, Signal Transducing
Adaptor Proteins, Vesicular Transport
Amino Acid Sequence
Animals
Antigens, CD
Antigens, Differentiation
CD3 Complex
CTLA-4 Antigen
GRB2 Adaptor Protein
Immunoconjugates

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Intracellular Signaling Peptides and Proteins

Lymphocyte Activation

Mice

Mice, Inbred C57BL

Molecular Sequence Data

Mutation

Phosphorylation

Source

Open in PubMed

Identifiers

PMID: 8638161
DOI: 10.1126/science.272.5265.1170

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8638161-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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