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Article

Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4.

Science (New York, N.Y.) - 24 May 1996

Marengère L E, Waterhouse P, Duncan G S, Mittrücker H W, Feng G S, Mak T W

Abstract excerpt

The absence of CTLA-4 results in uncontrolled T cell proliferation. The T cell receptor-specific kinases FYN, LCK, and ZAP-70 as well as the RAS pathway were found to be activated in T cells of Ctla-4-/- mutant mice. In addition, CTLA-4 specifically associated with the tyrosine phosphatase SYP, an interaction mediated by the SRC homology 2 (SH2) domains of SYP and the phosphotyrosine sequence Tyr-Val-Lys-Met...

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Source

Identifiers

PMID: 8638161
DOI: 10.1126/science.272.5265.1170

Genes

SYP
FYN
LCK
SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4.PMID 8638161Read ↗

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Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn).Semantic proximity Read ↗

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Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor proteinSemantic proximity Read ↗

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