Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling.

doi:10.1126/science.272.5265.1173

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Article

Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling.

Science (New York, N.Y.) - 24 May 1996

Plas D R, Johnson R, Pingel J T, Matthews R J, Dalton M, Roy G, Chan A C, Thomas M L

Abstract excerpt

The threshold at which antigen triggers lymphocyte activation is set by the enzymes that regulate tyrosine phosphorylation. Upon T cell activation, the protein tyrosine phosphatase SHP-1 was found to bind to the protein tyrosine kinase ZAP-70. This interaction resulted in an increase in SHP-1 pho...

Topics

Animals
Cell Line
HeLa Cells
Humans
Intracellular Signaling Peptides and Proteins
Lymphocyte Activation
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
Mutation
Phosphorylation
Phosphotyrosine
Protein Tyrosine Phosphatase, Non-Receptor Type 11

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Tyrosine Phosphatase, Non-Receptor Type 6

Protein Tyrosine Phosphatases

Protein-Tyrosine Kinases

Receptors, Antigen, T-Cell

Recombinant Fusion Proteins

Signal Transduction

T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 8638162
DOI: 10.1126/science.272.5265.1173

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8638162-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling.PMID 8638162Read ↗

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