Article
Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling.
Science (New York, N.Y.) - 24 May 1996
Plas D R, Johnson R, Pingel J T, Matthews R J, Dalton M, Roy G, Chan A C, Thomas M L
Abstract excerpt
The threshold at which antigen triggers lymphocyte activation is set by the enzymes that regulate tyrosine phosphorylation. Upon T cell activation, the protein tyrosine phosphatase SHP-1 was found to bind to the protein tyrosine kinase ZAP-70. This interaction resulted in an increase in SHP-1 phosphatase activity and a decrease in ZAP-70 kinase activity. Expression of a dominant negative mutant of SHP-1 in T...
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