Article
Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis.
Blood - 15 Feb 2005
Yu Joanne L, May Linda, Lhotak Vladimir, Shahrzad Siranoush, Shirasawa Senji, Weitz Jeffrey I, Coomber Brenda L, Mackman Nigel, Rak Janusz W
Abstract excerpt
Tissue factor (TF) is the primary cellular initiator of blood coagulation and a modulator of angiogenesis and metastasis in cancer. Indeed, systemic hypercoagulability in patients with cancer and TF overexpression by cancer cells are both closely associated with tumor progression, but their causes have been elusive. We now report that in human colorectal cancer cells, TF expression is under control of 2 major...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.