Article
Reduction in arthritis severity and modulation of immune function in tissue factor cytoplasmic domain mutant mice.
The American journal of pathology - 1 Jan 2004
Yang Yuan H, Hall Pam, Milenkovski Georgia, Sharma Laveena, Hutchinson Paul, Melis Els, Carmeliet Peter, Tipping Peter, Morand Eric
Abstract excerpt
Tissue factor (TF), a transmembrane receptor for plasma factor VII(a), is the main initiator of the coagulation cascade. It has also been implicated in noncoagulant processes, including inflammation. The function of the TF cytoplasmic domain was studied in mice in which 18 of the 20 cytoplasmic amino acids were deleted. This mutation (TF(deltaCT/deltaCT)) is not associated with alterations in blood coagulation....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.