Article
Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo.
The Journal of cell biology - 1 Jul 1995
Filardo E J, Brooks P C, Deming S L, Damsky C, Cheresh D A
Abstract excerpt
The NPXY sequence is highly conserved among integrin beta subunit cytoplasmic tails, suggesting that it plays a fundamental role in regulating integrin-mediated function. Evidence is provided that the NPXY structural motif within the beta 3 subunit, comprising residues 744-747, is essential for c...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Adhesion
- Cell Movement
- Chick Embryo
- Cricetinae
- Glycoproteins
- Integrins
- Lung Neoplasms
- Melanoma, Experimental
- Molecular Sequence Data
- Mutation
- Neoplasm Metastasis
- Oligopeptides
- Phenotype
- Receptors, Cytoadhesin
- Receptors, Vitronectin