Article
Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain.
Blood - 8 Sept 2011
Horowitz Netanel A, Blevins Elizabeth A, Miller Whitney M, Perry Ashley R, Talmage Kathryn E, Mullins Eric S, Flick Matthew J, Queiroz Karla C S, Shi Kun, Spek C Arnold, Conway Edward M, Monia Brett P, Weiler Hartmut, Degen Jay L, Palumbo Joseph S
Abstract excerpt
Thrombomodulin (TM) is a predominantly endothelial transmembrane glycoprotein that modulates hemostatic function through a domain that controls thrombin-mediated proteolysis and an N-terminal lectin-like domain that controls inflammatory processes. To test the hypothesis that TM is a determinant of malignancy and dissect the importance of these functional domains in cancer biology, metastatic potential was...
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