Article
Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation.
Proceedings of the National Academy of Sciences of the United States of America - 29 Aug 1995
Bromberg M E, Konigsberg W H, Madison J F, Pawashe A, Garen A
Abstract excerpt
Several studies have established a link between blood coagulation and cancer, and more specifically between tissue factor (TF), a transmembrane protein involved in initiating blood coagulation, and tumor metastasis. In the study reported here, a murine model of human melanoma metastasis was used...
Topics
- Animals
- Blood Coagulation
- Disease Models, Animal
- Female
- Humans
- Melanoma
- Mice
- Mice, SCID
- Mutation
- Thromboplastin
- Transfection
- Tumor Cells, Cultured