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Article

Tissue Factor and Cancer Metastasis: The Role of Intracellular and Extracellular Signaling Pathways

1 Jan 2004

Abstract excerpt

Tissue factor (TF) initiates the coagulation cascade but also plays a role in cancer and metastasis. This transmembrane protein is frequently upregulated on tumor cells and cells that show metastatic behavior. Furthermore, it is a significant risk factor for hepatic metastasis in patients suffering from colon cancer. Recently, it has been shown that TF, together with its natural ligand factor VIIa, induces...

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Identifiers

PMID: 15502877
DOI: 10.2119/2003-00047.versteeg

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Source receipt: pubmed, retrieved 7 Sept 2026.

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