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Article

Characterization of the product-inhibited complex in catalysis by human manganese superoxide dismutase.

The Journal of biological chemistry - 27 Aug 1999

Hearn A S, Tu C, Nick H S, Silverman D N

Abstract excerpt

The reduction with excess H(2)O(2) of human Mn(III) superoxide dismutase (SOD) and the active-site mutant Y34F Mn(III)SOD was measured by scanning stopped-flow spectrophotometry and revealed the presence of an intermediate in the reduction of the manganese. The visible absorption spectrum of this intermediate closely resembled that of the enzyme in the inhibited, zero-order phase of the catalyzed...

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Identifiers

PMID: 10455106
DOI: 10.1074/jbc.274.35.24457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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