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Article

Potent anti-tumor effects of an active site mutant of human manganese-superoxide dismutase. Evolutionary conservation of product inhibition.

The Journal of biological chemistry - 26 Mar 2004

Davis Christopher A, Hearn Amy S, Fletcher Bradley, Bickford Justin, Garcia Jorge E, Leveque Vincent, Melendez J Andres, Silverman David N, Zucali James, Agarwal Anupam, Nick Harry S

Abstract excerpt

Mn-SOD serves as the primary cellular defense against oxidative damage by converting superoxide radicals (O(2)(-)) to O(2) and H(2)O(2). A unique characteristic of this mitochondrial anti-oxidant enzyme is the conservation from bacteria to man of a rapidly formed product inhibited state. Using site-directed mutagenesis, we have generated an active site mutant (H30N) of human Mn-SOD, which exhibits significantly...

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PMID: 14688256
DOI: 10.1074/jbc.M310623200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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