Article
Detoxification of superoxide without production of H2O2: antioxidant activity of superoxide reductase complexed with ferrocyanide.
Proceedings of the National Academy of Sciences of the United States of America - 3 Oct 2006
Molina-Heredia Fernando P, Houée-Levin Chantal, Berthomieu Catherine, Touati Danièle, Tremey Emilie, Favaudon Vincent, Adam Virgile, Nivière Vincent
Abstract excerpt
The superoxide radical O(2)(-.) is a toxic by-product of oxygen metabolism. Two O(2)(-.) detoxifying enzymes have been described so far, superoxide dismutase and superoxide reductase (SOR), both forming H2O2 as a reaction product. Recently, the SOR active site, a ferrous iron in a [Fe(2+) (N-His)(4) (S-Cys)] pentacoordination, was shown to have the ability to form a complex with the organometallic compound...
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