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Article

The effects of mitochondrial iron homeostasis on cofactor specificity of superoxide dismutase 2.

The EMBO journal - 19 Apr 2006

Yang Mei, Cobine Paul A, Molik Sabine, Naranuntarat Amornrat, Lill Roland, Winge Dennis R, Culotta Valeria C

Abstract excerpt

Many metalloproteins have the capacity to bind diverse metals, but in living cells connect only with their cognate metal cofactor. In eukaryotes, this metal specificity can be achieved through metal-specific metallochaperone proteins. Herein, we describe a mechanism whereby Saccharomyces cerevisiae manganese superoxide dismutase (SOD2) preferentially binds manganese over iron based on the differential...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16601688
DOI: 10.1038/sj.emboj.7601064
PMCID: PMC1440838

Genes

SOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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