Article
Evidence for heme oxygenase activity in a heme peroxidase.
Biochemistry - 9 Jun 2009
Badyal Sandip K, Eaton Graham, Mistry Sharad, Pipirou Zoi, Basran Jaswir, Metcalfe Clive L, Gumiero Andrea, Handa Sandeep, Moody Peter C E, Raven Emma Lloyd
Abstract excerpt
The heme peroxidase and heme oxygenase enzymes share a common heme prosthetic group but catalyze fundamentally different reactions, the first being H(2)O(2)-dependent oxidation of substrate using an oxidized Compound I intermediate, and the second O(2)-dependent degradation of heme. It has been proposed that these enzymes utilize a common reaction intermediate, a ferric hydroperoxide species, that sits at a...
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