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Article

Requirement for Shc in TCR-mediated activation of a T cell hybridoma.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 1999

Pratt J C, van den Brink M R, Igras V E, Walk S F, Ravichandran K S, Burakoff S J

Abstract excerpt

Engagement of the TCR determines the fate of T cells to activate their functional programs, proliferate, or undergo apoptosis. The intracellular signal transduction pathways that dictate the specific outcome of receptor engagement have only been partially elucidated. The adapter protein, Shc, is involved in cytokine production, mitogenesis, transformation, and apoptosis in different cell systems. We found that...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 10452997

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Requirement for Shc in TCR-mediated activation of a T cell hybridoma.PMID 10452997Read ↗

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