Requirement for Shc in TCR-mediated activation of a T cell hybridoma.

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Article

Requirement for Shc in TCR-mediated activation of a T cell hybridoma.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 1999

Pratt J C, van den Brink M R, Igras V E, Walk S F, Ravichandran K S, Burakoff S J

Abstract excerpt

Engagement of the TCR determines the fate of T cells to activate their functional programs, proliferate, or undergo apoptosis. The intracellular signal transduction pathways that dictate the specific outcome of receptor engagement have only been partially elucidated. The adapter protein, Shc, is involved in cytokine production, mitogenesis, transformation, and apoptosis in different cell systems. We found that...

Topics

Adaptor Proteins, Signal Transducing
Adaptor Proteins, Vesicular Transport
Animals
Apoptosis
Calcium-Calmodulin-Dependent Protein Kinases
Cell Line
Fas Ligand Protein
GRB2 Adaptor Protein
Hybridomas
Interleukin-2
Ligands
Lymphocyte Activation
Membrane Glycoproteins

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mutation

Phosphorylation

Point Mutation

Protein Biosynthesis

Source

Open in PubMed

Identifiers

PMID: 10452997

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