Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins.

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Article

Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins.

Oncogene - 1 Oct 1994

Salcini A E, McGlade J, Pelicci G, Nicoletti I, Pawson T, Pelicci P G

Abstract excerpt

The mammalian SHC gene encodes three overlapping proteins which all contain a carboxy-terminal SH2 domain. Shc proteins are phosphorylated on tyrosine by a variety of receptor and cytoplasmic tyrosine kinases. Phosphorylated Shc proteins form a complex with the SH2-SH3 containing Grb2 protein which is implicated in the regulation of Ras, suggesting that Shc is involved in the intracellular transmission of growth...

Topics

3T3 Cells
Adaptor Proteins, Signal Transducing
Adaptor Proteins, Vesicular Transport
Amino Acid Sequence
Animals
Binding Sites
Cell Line
Cell Transformation, Neoplastic
GRB2 Adaptor Protein
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Phosphorylation

Proteins

Shc Signaling Adaptor Proteins

Src Homology 2 Domain-Containing, Transforming Protein 1

Tyrosine

Source

Open in PubMed

Identifiers

PMID: 8084588

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8084588-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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