Differentiation induced by the c-Mpl cytokine receptor is blocked by mutant Shc adaptor protein.

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Article

Differentiation induced by the c-Mpl cytokine receptor is blocked by mutant Shc adaptor protein.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Sept 1996

Hill R J, Zozulya S, Lu Y L, Hollenbach P W, Joyce-Shaikh B, Bogenberger J, Gishizky M L

Abstract excerpt

c-Mpl, a member of the cytokine receptor superfamily, induces both proliferative and differentiation responses when stimulated with its ligand thrombopoietin (TPO). To examine signal transduction pathways associated with differentiation versus proliferation, 32D clone 3 cells, a murine interleuki...

Topics

Animals
Calcium-Calmodulin-Dependent Protein Kinases
Cell Differentiation
Cell Division
Cell Line
Granulocyte Colony-Stimulating Factor
Granulocytes
Humans
Interleukin-3
Mice
Mitogens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neoplasm Proteins

Phosphoproteins

Phosphorylation

Phosphotyrosine

Proteins

Proto-Oncogene Proteins

Source

Open in PubMed

Identifiers

PMID: 8877093

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8877093-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Differentiation induced by the c-Mpl cytokine receptor is blocked by mutant Shc adaptor protein.PMID 8877093Read ↗

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