Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of interleukin-3-induced substrate phosphorylation and cell survival by SHP-2 (Src-homology protein tyrosine phosphatase 2).

The Biochemical journal - 15 Nov 2003

Wheadon Helen, Edmead Christine, Welham Melanie J

Abstract excerpt

The cytosolic SHP-2 (Src homology protein tyrosine phosphatase 2) has previously been implicated in IL-3 (interleukin-3) signalling [Bone, Dechert, Jirik, Schrader and Welham (1997) J. Biol. Chem. 272, 14470 -14476; Craddock and Welham (1997) J. Biol. Chem. 272, 29281-29289; Welham, Dechert, Leslie, Jirik and Schrader (1994) J. Biol. Chem. 269, 23764-23768; Qu, Nguyen, Chen and Feng (2001) Blood 97, 911-914]. To...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Interleukin-3
Share to Milk Proteins
Share to Mitogen-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Platelet Endothelial Cell Adhesion Molecule-1

Share to Protein Phosphatase 2

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

Share to Protein Tyrosine Phosphatases

Share to STAT5 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 12935294
DOI: 10.1042/BJ20031160
PMCID: PMC1223759

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of interleukin-3-induced substrate phosphorylation and cell survival by SHP-2 (Src-homology protein tyrosine phosphatase 2).PMID 12935294Read ↗

Catalytic-dependent and -independent roles of SHP-2 tyrosine phosphatase in interleukin-3 signaling.Semantic proximity Read ↗

The role of SHIP in cytokine-induced signaling.Semantic proximity Read ↗

Modulation of the nuclear factor kappa B pathway by Shp-2 tyrosine phosphatase in mediating the induction of interleukin (IL)-6 by IL-1 or tumor necrosis factor.Semantic proximity Read ↗

Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors.Semantic proximity Read ↗

The novel role of the C-terminal region of SHP-2. Involvement of Gab1 and SHP-2 phosphatase activity in Elk-1 activation.Semantic proximity Read ↗

Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2.Semantic proximity Read ↗

IL-2 receptor signaling through the Shb adapter protein in T and NK cells.Semantic proximity Read ↗

The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling.Semantic proximity Read ↗

Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling.Semantic proximity Read ↗

Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2.Semantic proximity Read ↗

SHP-2 regulates growth factor dependent vascular signalling and function.Semantic proximity Read ↗

New activation modus of STAT3: a tyrosine-less region of the interleukin-22 receptor recruits STAT3 by interacting with its coiled-coil domain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.