Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IL-2 receptor signaling through the Shb adapter protein in T and NK cells.

Biochemical and biophysical research communications - 30 Aug 2002

Lindholm Cecilia K

Abstract excerpt

Interleukin-2 induces heterodimerization of the IL-2 receptor beta and gamma subunits. This study addresses a role of the Shb adapter protein in IL-2 receptor signaling in T and NK cells. The IL-2Rbeta and gamma chains were found to co-immunoprecipitate with Shb, when each alone was co-expressed with Shb in COS cells. Using fusion proteins, the Shb SH2 domain was found to associate in a phosphotyrosine-dependent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD56 Antigen
Share to Janus Kinase 1
Share to Janus Kinase 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Peptide Biosynthesis

Share to Phenylalanine

Share to Precipitin Tests

Share to Proline

Share to Receptors, Interleukin-2

Source

Identifiers

PMID: 12200137
DOI: 10.1016/s0006-291x(02)02016-8

Genes

JAK1
JAK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IL-2 receptor signaling through the Shb adapter protein in T and NK cells.PMID 12200137Read ↗

The Emerging and Diverse Roles of Src‐Like Adaptor Proteins in Health and DiseaseSemantic proximity Read ↗

Requirement for Shc in TCR-mediated activation of a T cell hybridoma.Semantic proximity Read ↗

Association of the X-linked lymphoproliferative disease gene product SAP/SH2D1A with 2B4, a natural killer cell-activating molecule, is dependent on phosphoinositide 3-kinase.Semantic proximity Read ↗

SLAM-associated protein as a potential negative regulator in Trk signaling.Semantic proximity Read ↗

Shb deficient mice display an augmented TH2 response in peripheral CD4+ T cells.Semantic proximity Read ↗

STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction.Semantic proximity Read ↗

Dephosphorylation of the adaptor LAT and phospholipase C-γ by SHP-1 inhibits natural killer cell cytotoxicity.Semantic proximity Read ↗

Regulation of interleukin-3-induced substrate phosphorylation and cell survival by SHP-2 (Src-homology protein tyrosine phosphatase 2).Semantic proximity Read ↗

The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells.Semantic proximity Read ↗

Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3 signalingSemantic proximity Read ↗

Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2.Semantic proximity Read ↗

The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.