Article
Inhibition of CD4/p56lck signaling by a dominant negative mutant of the Shc adaptor protein.
Oncogene - 16 Mar 1995
Baldari C T, Pelicci G, Di Somma M M, Milia E, Giuli S, Pelicci P G, Telford J L
Abstract excerpt
T-cell antigen receptor stimulation results in phosphorylation of the SH2 containing Shc proteins and recruitment of the Grb2/mSos complex suggesting that Shc proteins are involved in transducing T-cell activating signals to Ras. We have measured the effects of the isolated Shc-SH2 domain and the...
Topics
- Base Sequence
- CD4 Antigens
- Cell Line
- Chloramphenicol O-Acetyltransferase
- DNA, Complementary
- DNA-Binding Proteins
- Genes, Dominant
- Humans
- Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
- Molecular Sequence Data
- Mutation
- NFATC Transcription Factors
- Nuclear Proteins
- Phosphorylation
- Protein-Tyrosine Kinases
- Signal Transduction
- Transcription Factors
- Tyrosine