Article
Inhibition of CD4/p56lck signaling by a dominant negative mutant of the Shc adaptor protein.
Oncogene - 16 Mar 1995
Baldari C T, Pelicci G, Di Somma M M, Milia E, Giuli S, Pelicci P G, Telford J L
Abstract excerpt
T-cell antigen receptor stimulation results in phosphorylation of the SH2 containing Shc proteins and recruitment of the Grb2/mSos complex suggesting that Shc proteins are involved in transducing T-cell activating signals to Ras. We have measured the effects of the isolated Shc-SH2 domain and the dominant negative RasN17 protein on activation of the T-cell specific transcription factor NF-AT. The isolated Shc-SH2...
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