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Article

Methionine synthase: high-resolution mapping of the human gene and evaluation as a candidate locus for neural tube defects.

Molecular genetics and metabolism - 1 Aug 1999

Brody L C, Baker P J, Chines P S, Musick A, Molloy A M, Swanson D A, Kirke P N, Ghosh S, Scott J M, Mills J L

Abstract excerpt

Periconceptual folate supplementation has been found to prevent the occurrence of many neural tube defects (NTDs). Consequently, genetic variation in folate metabolism genes is expected to contribute to the risk for neural tube defects. Methionine synthase catalyzes the vitamin B(12)-dependent conversion of homocysteine and 5-methyltetrahydrofolate to methionine and tetrahydrofolate. The observation that...

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PMID: 10444343
DOI: 10.1006/mgme.1999.2881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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