Article
Analysis of methionine synthase reductase polymorphisms for neural tube defects risk association.
Molecular genetics and metabolism - 1 Jul 2005
O'Leary Valerie B, Mills James L, Pangilinan Faith, Kirke Peadar N, Cox Christopher, Conley Mary, Weiler Andrea, Peng Kun, Shane Barry, Scott John M, Parle-McDermott Anne, Molloy Anne M, Brody Lawrence C
Abstract excerpt
Methionine synthase reductase (MTRR) regenerates methylated cobalamin levels from the oxidised cob(II)alamin form and in so doing plays a crucial role in maintaining the active state of methionine synthase (MTR). MTR is an essential enzyme catalyzing the conversion of homocysteine to methionine. Single nucleotide polymorphisms (SNPs) within the MTRR gene may potentially compromise MTR activity leading to elevated...
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