Article
Evaluation of transcobalamin II polymorphisms as neural tube defect risk factors in an Irish population.
Birth defects research. Part A, Clinical and molecular teratology - 1 Apr 2005
Swanson Deborah A, Pangilinan Faith, Mills James L, Kirke Peadar N, Conley Mary, Weiler Andrea, Frey Tiffany, Parle-McDermott Anne, O'Leary Valerie B, Seltzer Rebecca R, Moynihan Kathryn A, Molloy Anne M, Burke Helen, Scott John M, Brody Lawrence C
Abstract excerpt
BACKGROUND: Decreased maternal folate levels are associated with having a child with a neural tube defect (NTD), and periconceptual folic acid supplementation reduces this risk by >50%. Vitamin B(12) (as methylcobalamin) is a cofactor for methionine synthase, an enzyme that plays a key role in folate metabolism. Alterations in vitamin B(12) metabolism may influence the development of NTDs. Low levels of maternal...
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