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Cloning, mapping and RNA analysis of the human methionine synthase gene

1 Dec 1996

Abstract excerpt

Elevated levels of plasma homocysteine is a risk factor in both birth defects and vascular disease. Methionine synthase (MS) is a cobalamin dependent enzyme which catalyzes methylation of homocysteine to methionine. Impaired MS activity is expected to lead to increased levels of plasma homocysteine. In addition, defects in this gene may underlie the methionine-dependence observed in a number of human tumor cell...

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PMID: 8968735
DOI: 10.1093/hmg/5.12.1851

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