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Article

Construction of a high resolution linkage disequilibrium map to evaluate common genetic variation in TP53 and neural tube defect risk in an Irish population.

American journal of medical genetics. Part A - 15 Oct 2008

Pangilinan Faith, Geiler Kerry, Dolle Jessica, Troendle James, Swanson Deborah A, Molloy Anne M, Sutton Marie, Conley Mary, Kirke Peadar N, Scott John M, Mills James L, Brody Lawrence C

Abstract excerpt

Genetic and environmental factors contribute to the etiology of neural tube defects (NTDs). While periconceptional folic acid supplementation is known to significantly reduce the risk of NTDs, folate metabolic pathway related factors do not account for all NTDs. Evidence from mouse models indicates that the tumor protein p53 (TP53) is involved in implantation and normal neural tube development. To determine...

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Identifiers

PMID: 18798306
DOI: 10.1002/ajmg.a.32504
PMCID: PMC2836760

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MDM2

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