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Article

pH dependence of antibody: hapten association.

Molecular immunology - 1 Apr 1999

Livesay D, Linthicum S, Subramaniam S

Abstract excerpt

Monoclonal antibody NC6.8 is specific for the superpotent sweetener, N-(p-cyanophenyl)-N'-(diphenylmethyl)-guanidiniumacetic++ + acid. The three-dimensional structure of the complex shows the close proximity of complementary charged residues on the antibody and groups of the hapten. As a result, association is dependent on the pH, dielectric, and ionic strength of the medium. Continuum electrostatics methods are...

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Identifiers

PMID: 10444003
DOI: 10.1016/s0161-5890(99)00026-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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