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Article

Structural origins of efficient proton abstraction from carbon by a catalytic antibody.

Proceedings of the National Academy of Sciences of the United States of America - 5 Apr 2005

Debler Erik W, Ito Shuichiro, Seebeck Florian P, Heine Andreas, Hilvert Donald, Wilson Ian A

Abstract excerpt

Antibody 34E4 catalyzes the conversion of benzisoxazoles to salicylonitriles with high rates and multiple turnovers. The crystal structure of its complex with the benzimidazolium hapten at 2.5-angstroms resolution shows that a combination of hydrogen bonding, pi stacking, and van der Waals interactions is exploited to position both the base, Glu(H50), and the substrate for efficient proton transfer. Suboptimal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15788533
DOI: 10.1073/pnas.0409207102
PMCID: PMC555987

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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