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Article

Computer modeling of electrostatic steering and orientational effects in antibody-antigen association.

Biophysical journal - 1 Mar 1995

Kozack R E, d'Mello M J, Subramaniam S

Abstract excerpt

Brownian dynamics simulations are performed to investigate the role of long-range electrostatic forces in the association of the monoclonal antibody HyHEL-5 with hen egg lysozyme. The electrostatic field of the antibody is obtained from a solution of the nonlinear Poisson-Boltzmann using the x-ray crystal coordinates of this protein. The lysozyme is represented as an asymmetric dumbell consisting of two spheres...

Topics

Animals
Antibodies, Monoclonal
Antigen-Antibody Reactions
Biophysical Phenomena
Biophysics
Chickens
Computer Simulation
Electrochemistry
Female
Models, Biological
Models, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muramidase

Mutation

Thermodynamics

Source

Open in PubMed Open full text

Identifiers

PMID: 7756548
DOI: 10.1016/S0006-3495(95)80257-2
PMCID: PMC1281805

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7756548-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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