Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Computer modeling of electrostatic steering and orientational effects in antibody-antigen association.

Biophysical journal - 1 Mar 1995

Kozack R E, d'Mello M J, Subramaniam S

Abstract excerpt

Brownian dynamics simulations are performed to investigate the role of long-range electrostatic forces in the association of the monoclonal antibody HyHEL-5 with hen egg lysozyme. The electrostatic field of the antibody is obtained from a solution of the nonlinear Poisson-Boltzmann using the x-ray crystal coordinates of this protein. The lysozyme is represented as an asymmetric dumbell consisting of two spheres...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to Chickens
Share to Computer Simulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Models, Biological

Share to Models, Molecular

Share to Muramidase

Share to Mutation

Share to Thermodynamics

Source

Open in PubMed Open full text

Identifiers

PMID: 7756548
DOI: 10.1016/S0006-3495(95)80257-2
PMCID: PMC1281805

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Computer modeling of electrostatic steering and orientational effects in antibody-antigen association.PMID 7756548Read ↗

pH dependence of antibody/lysozyme complexation.Semantic proximity Read ↗

Shape and electrostatic complementarity at viral antigen-antibody complexes.Semantic proximity Read ↗

The role of amino acid sequence in the self-association of therapeutic monoclonal antibodies: insights from coarse-grained modeling.Semantic proximity Read ↗

Thermodynamics of antibody-antigen interaction revealed by mutation analysis of antibody variable regions.Semantic proximity Read ↗

Protein-protein association: investigation of factors influencing association rates by brownian dynamics simulations.Semantic proximity Read ↗

Analysis of protein-protein interactions and the effects of amino acid mutations on their energetics. The importance of water molecules in the binding epitope.Semantic proximity Read ↗

Association of the anti-hen egg lysozyme antibody HyHEL-5 with avian species variant and mutant lysozymes.Semantic proximity Read ↗

Free energy simulations of the HyHEL-10/HEL antibody-antigen complex.Semantic proximity Read ↗

A molecular dynamics simulation of the human lysozyme - camelid VHH HL6 antibody system.Semantic proximity Read ↗

Darwinian biophysics: electrostatics and evolution in the kinetics of molecular binding.Semantic proximity Read ↗

Local environment effects on charged mutations for developing aggregation-resistant monoclonal antibodies.Semantic proximity Read ↗

Structure of an antibody-lysozyme complex unexpected effect of conservative mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.