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Article

pH effects on binding between the anthrax protective antigen and the host cellular receptor CMG2.

Protein science : a publication of the Protein Society - 1 Oct 2012

Rajapaksha Maheshinie, Lovell Scott, Janowiak Blythe E, Andra Kiran K, Battaile Kevin P, Bann James G

Abstract excerpt

The anthrax protective antigen (PA) binds to the host cellular receptor capillary morphogenesis protein 2 (CMG2) with high affinity. To gain a better understanding of how pH may affect binding to the receptor, we have investigated the kinetics of binding as a function of pH to the full-length monomeric PA and to two variants: a 2-fluorohistidine-labeled PA (2-FHisPA), which is ∼1 pH unit more stable to variations...

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Identifiers

PMID: 22855243
DOI: 10.1002/pro.2136
PMCID: PMC3526989

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Source receipt: pubmed, retrieved 7 Sept 2026.

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