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Article

Critical contribution of aromatic rings to specific recognition of polyether rings. The case of ciguatoxin CTX3C-ABC and its specific antibody 1C49.

The Journal of biological chemistry - 2 May 2008

Tsumoto Kouhei, Yokota Akiko, Tanaka Yoshikazu, Ui Mihoko, Tsumuraya Takeshi, Fujii Ikuo, Kumagai Izumi, Nagumo Yoko, Oguri Hiroki, Inoue Masayuki, Hirama Masahiro

Abstract excerpt

To address how proteins recognize polyether toxin compounds, we focused on the interaction between the ABC ring compound of ciguatoxin 3C and its specific antibody, 1C49. Surface plasmon resonance analyses indicated that Escherichia coli-expressed variable domain fragments (Fv) of 1C49 had the high affinity constants and slow dissociation constants typical of antigen-antibody interactions. Linear van't Hoff...

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PMID: 18326040
DOI: 10.1074/jbc.M710553200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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